Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor‐2 Secretion
Tereza Vanova et al. STEM CELLS
In this study, the authors identify tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase as a novel regulator of fibroblast growth factor (FGF)-2-mediated pluripotency of human pluripotent stem cells. The study shows that TEC-mediated FGF2 secretion is essential for self-renewal of these cells and that TEC is involved in their early cell fate decisions.
Treatment of Breast Cancer‐Related Lymphedema with Adipose‐Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study
Navid Mohamadpour Toyserkani et al. STEM CELLS Translational Medicine
Lymphedema is one of the most serious and debilitating late complications following breast cancer surgery with lackluster treatment opportunities. Cell therapy has shown promising results in preclinical models of lymphedema. Autologous adipose tissue is the most convenient source of cells for clinical therapy. In the present First in Human Pilot Study, it is shown that treatment with autologous adipose-derived regenerative cells can alleviate symptoms and reduce the need for other treatment options during the 6 months follow-up. The treatment proved safe without any noteworthy adverse events. Randomized controlled trials will be needed to verify the positive results.
Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient‐Specific Genomic Aberrations
Kyle R. Salci, et al. STEM CELLS
Generation of AML patient-specific Fib iPSCs establishes a cellular platform from which to derive healthy HPCs that are devoid of leukemia-associated aberration detected in the patients' BM. These autologous HPCs also possess normal in vitro differentiation capacity to multiple myeloid lineages as compared to the patients' dysfunctional AML blasts. This work provides proof of principle that derivation of healthy autologous sources of blood using cellular reprogramming is possible, and should enable more AML patients to receive safe transplantations during therapy toward increasing the rate of disease-free survival.
Endochondral Ossification in Critical-Sized Bone Defects via Readily Implantable Scaffold-Free Stem Cell Constructs
Phuong N. Dang et al., STEM CELLS Translational MedicineUsing a scaffold-free high-density stem cell system capable of controlled growth factor delivery from incorporated microparticles, enhanced healing of critical-sized calvarial bone defects via endochondral bone formation was achieved within 4 weeks without the need for long term in vitro culture prior to implantation. The microparticle-based delivery system provides controlled local presentation of growth factors to cells, avoiding the need for expensive and lengthy in vitro culture that requires repeated growth factor supplementation. This work lays the foundation for a rapidly implantable regenerative medicine therapy that accelerates endochondral ossification, the body's natural bone repair process. The modular nature of this system lends itself well to the utilization of different cell types and/or bioactive factors to engineer other complex tissues.STEM CELLS
Video abstract from Dr. Cooke, et al. on his recently published STEM CELLS paper entitled, "Retinoic Acid Inducible Gene 1 Protein (RIG1)-like Receptor Pathway is Required for Efficient Nuclear Reprogramming." Read the paper here.
Video abstract from Drs. Cox, Hetz, Liao, Aertker, Ewing-Cobbs, Juranek, Savitz, Jackson, Romanowska-Pawliczek, Triolo, Dash, Pedroza, Lee, Worth, Aisiku, Choi, Holcomb, and Kitagawa on their recently published STEM CELLS paper entitled, "Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells." Read the paper here.Video Library