Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single‐Center Phase I Open‐Label Trial
Geraldine Dawson, Jessica M. Sun, Katherine S. Davlantis, Michael Murias, Lauren Franz, Jesse Troy, Ryan Simmons, Maura Sabatas-DeVito, Rebecca Durham, Joanne Kurtzberg, STEM CELLS Translational Medicine
This phase I study demonstrates that it is safe and feasible to perform autologous umbilical cord blood infusions in young children with autism spectrum disorder and identifies several promising outcome measures for use in future trials.
Read the related CNN article here.
Transplantation of CD51+ Stem Leydig Cells: A New Strategy for the Treatment of Testosterone Deficiency
Zhi Jun Zang et al., STEM CELLS
Androgen replacement therapy is a straightforward treatment for male hypogonadism, but comes with the risk of serious side effects. Transplantation of stem Leydig cells (SLCs) will provide a new strategy for treating testosterone deficiency. This new study demonstrates that prospectively isolated CD51+ cells from the testes of adult mice have SLCs properties in vitro. After transplantation, the CD51+ SLCs can differentiate to mature LCs, be regulated by the hypothalamic-pituitary-gonadal axis, and restore testosterone production with circadian rhythm.
Jean L. Tan et al., STEM CELLS Translational Medicine
In this study, stem-like cells derived from the human placenta, called human amnion epithelial cells (hAECs), were shown to prevent lung injury by producing a lipid-based molecule called lipoxin A4. This molecule works by encouraging interactions between a variety of immune cells in the lungs to effect repair. Following hAEC administration, fewer proinflammatory immune cells were attracted to the lungs and their activity was suppressed to achieve resolution of lung injury. The findings from this study will help in the design of safe and efficacious hAEC therapy for lung disease.
Retinoic Acid Inducible Gene 1 Protein (RIG1)‐Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming
Nazish Sayed et al., STEM CELLS
The authors build on their studies showing a critical role for activation of innate immunity in nuclear reprogramming. Similar to toll-like receptor 3, the retinoic acid-inducible gene 1 receptor (RIG-1)-like receptor (RLR) pathway senses viral RNA. Using retroviral or modified messenger RNA approaches, the study shows that this signaling pathway is critical to nuclear reprogramming. Results of loss and gain of function studies demonstrate that this pathway is necessary for the gene expression and epigenetic changes to generate induced pluripotent stem cell colonies.
Improvement of In Vitro Three‐Dimensional Cartilage Regeneration by a Novel Hydrostatic Pressure Bioreactor
Jie Chen et al., STEM CELLS Translational Medicine
Inferior mechanical strength and tissue homogeneity of in vitro engineered three-dimensional (3D) cartilage greatly restricted its clinical translation. The current study developed a hydrostatic pressure (HP) bioreactor based on a novel pressure-transmitting mode, which efficiently avoided potential risks of the previously reported bioreactors in culture environment and contamination controls. The newly developed bioreactor realized stable long-term culture under high HP and efficiently promoted in vitro 3D cartilage formation by improving its mechanical strength, cartilage regeneration thickness, tissue homogeneity, cell proliferation, extracellular matrix contents, and collagen cross-linking level. This study provided a highly efficient and stable bioreactor system for improving in vitro 3D cartilage regeneration and thus helped to accelerate the clinical translation of this system.
Video abstract from Dr. Cooke, et al. on his recently published STEM CELLS paper entitled, "Retinoic Acid Inducible Gene 1 Protein (RIG1)-like Receptor Pathway is Required for Efficient Nuclear Reprogramming." Read the paper here.
Video abstract from Drs. Cox, Hetz, Liao, Aertker, Ewing-Cobbs, Juranek, Savitz, Jackson, Romanowska-Pawliczek, Triolo, Dash, Pedroza, Lee, Worth, Aisiku, Choi, Holcomb, and Kitagawa on their recently published STEM CELLS paper entitled, "Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells." Read the paper here.Video Library