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The Best Papers from our 2016 Young Investigators

Last updated:
6 January 2017
The STEM CELLS Translational Medicine Young Investigator Award honors a young scientist who is principal author of a significant research paper published in STEM CELLS Translational Medicine. The 4th annual award went to Thorsten R. Döppner, M.D. Here, we feature Dr. Döppner’s paper as chosen by a panel of judges composed of our Senior Editors.


“Stem Cells Translational Medicine is delighted to honor Dr. Döppner for his innovative research suggesting a potential new treatment for stroke,” said Anthony Atala, M.D., Editor-in-Chief of SCTM and director of the Wake Forest Institute for Regenerative Medicine. “Strokes cause one of every 20 deaths in the U.S. and also cause significant disability. Dr. Döppner’s work is a novel approach that shows significant promise in pre-clinical studies.”


Below are the finalists for the 2016 award. The STEM CELLS Translational Medicine Editors support the efforts of these emerging researchers and encourage the development of these young investigators who are making significant impacts in this field, thus fostering the future of their clinical applications.


Most Influential Articles from the Stem Cell Sister Journals

Last updated:
5 January 2017
A Note from Terry R.J. Lappin, Concise Review Editor for the Sister Journals


The major challenge confronting regenerative medicine is to find safe practical procedures to harness the potential of stem cells for long term clinical benefit. Two key objectives of the escalating efforts in stem cell research are to develop a deep understanding of stem cell biology, and to apply this knowledge to exploit novel therapeutic options.


STEM CELLS and STEM CELLS Translational Medicine focus on these areas, covering a diverse array of preclinical and clinical research.


The 14 well-cited articles selected for this special issue attest to the depth and breadth of recent publications in the Sister Journals. They report studies on exosomes, mesenchymal stem cells and induced pluripotent stem cells which were designed to clarify mechanisms of differentiation, mechanosensitivity and immunosuppression, using cutting-edge techniques such as lineage tracing and CRISPR/Cas9. These approaches have provided valuable insights into neuroregeneration, angiogenesis, hematopoiesis, cancer progression, aging and wound healing. Practical issues such as the source, stage of development and purity of donor cells and the use of xeno-free media are also discussed.


The Editors hope that you will enjoy browsing this eclectic collection of recent manuscripts from STEM CELLS and STEM CELLS Translational Medicine, and that their continuing commitment to the Sister Journals will make a useful contribution to the ongoing progress of regenerative medicine.

The Best Papers from our 2015 Young Investigators

Last updated:
4 January 2017
The STEM CELLS Translational Medicine Young Investigator Award honors a young scientist who is principal author of a significant research paper published in STEM CELLS Translational Medicine. The 3rd annual award went to Dustin R. Wakeman, Ph.D. Here, we feature Dr. Wakeman’s papers as chosen by a panel of judges composed of our Senior Editors. Below are the finalists for the 2015 award. The STEM CELLS Translational Medicine Editors support the efforts of these emerging researchers and encourage the development of these young investigators who are making significant impacts in this field, thus fostering the future of their clinical applications.

New Strategies in Tissue Engineering and Regenerative Medicine

Last updated:
3 January 2017
Stem cells are a powerful resource for producing a variety of cell types to be used in translational medicine. Translational medicine represents a new era in medicine by "translating" basic biological research into biomedical applications aimed to improve health outcomes of patients with a variety of chronic diseases that lack clinically effective therapies. This constantly evolving field draws from the strengths of multidisciplinary approaches including biology, chemistry, physics, bioengineering, and material science to develop novel approaches for stem cell therapy and tissue regeneration. The exponential growth in research studies covering regenerative medicine has given rise to cell-based treatments for regeneration of skin, nerve, cartilage, cardiac, and other critical organ tissues. This virtual collection provides original research and literature reviews that contribute to the fields of tissue engineering and regenerative medicine by reporting on new strategies with the potential to be fully realized for the treatment of tissues and damaged organs.


Editor's Note
by Terry R.J. Lappin, Concise Review Editor of STEM CELLS and STEM CELLS Translational Medicine.


Tissue engineering and regenerative medicine are burgeoning branches of translational research which have the potential to heal damaged tissues and organs. These selected articles, recently published in STEM CELLS Translational Medicine, illustrate the range of current investigations and provide valuable insights into this rapidly evolving area of medicine.


Tissue engineering evolved from the study of biomaterials and recent advances have utilised combinations of biologically active agents, cells and scaffolds to promote tissue replacement. Frith and colleagues (2014) have reviewed microRNA-based tissue regeneration, and Aoi and colleagues (2012) found that 1α,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells signifying its therapeutic potential for hair regeneration


Nam et al. (2014) identified xiphoid process-derived chondrocytes as a source of cartilage with properties likely to be useful in reconstruction of elastic cartilage. Shen et al. (2014) showed that intra-articular injection of human meniscus stem/progenitor cells (hMeSPCs) enhanced meniscus regeneration through the SDF-1/CXCR4 axis in a rat model, suggesting a new clinical strategy for meniscus regeneration. Blais and co-workers (2013) describe the characteristics of extensive burns and current treatments including the use of tissue-engineered skin.


In the dental domain, Iohara et al. (2013) describe a novel, safe, and efficacious combinatorial therapy for pulp/dentine regeneration using granulocyte colony-stimulating factor and pulp stem cells, and Monsarrat and colleagues (2014) provide a comprehensive review of value of mesenchymal stromal cells for periodontal regeneration.


A major goal in regenerative medicine is to develop a therapy to ameliorate or even reverse disease progression in chronic heart failure. In an already highly cited paper Koudstaal and colleagues (2013) discuss the status of the cardioregenerative field, summarizing the current knowledge of cardiac stem/progenitor cells as the regenerative substrate in the adult heart, and their use in preclinical and clinical studies to repair the injured myocardium. Cantero Peral and collaborators (2015) demonstrate that autologous umbilical cord mononuclear cells (UCB-MNCs) can be transplanted safely into the right ventricle of juvenile porcine hearts, providing a further stepping stone to advance cell-based therapies towards clinical trials for congenital heart disease.


Among the enabling technologies for cell-based clinical translation, de Windt et al. (2014) review the cell interactions which steer cartilage regeneration, Titmarsh et al. (2014) report on recent developments in microfluidic technology and Barrett et al. (2014) demonstrate that induced pluripotent stem cells can be reliably generated from lymphoblastoid cell lines and have the potential to provide worldwide repositories to generate new human iPSC cell lines for disease modeling, drug discovery and other applications in regenerative medicine.

The Best Papers from our 2014 Young Investigators

Last updated:
2 January 2017
The STEM CELLS Translational Medicine Young Investigator Award honors a young scientist who is principal author of a significant research paper published in STEM CELLS Translational Medicine. The STEM CELLS Translational Medicine Editors support the efforts of these emerging researchers and encourage the development of these young investigators who are making significant impacts in this field, thus fostering the future of their clinical applications. Below are the finalists for the 2014 award.

Special Collection for ISSCR 2014

Last updated:
30 December 2016
To complement presentations at the 2014 ISSCR Annual Meeting, STEM CELLS Translational Medicine is please to present this special collection of papers.

The Best Papers from our 2013 Young Investigators

Last updated:
29 December 2016
STEM CELLS Translational Medicine presented Dr. Laura Shin with its first Young Investigator Award in December 2013. The STEM CELLS Translational Medicine Young Investigator Award honors a young scientist who is principal author of a significant research paper published in STEM CELLS Translational Medicine. The STEM CELLS Translational Medicine Editors support the efforts of these emerging researchers and encourage the development of these young investigators who are making significant impacts in this field, thus fostering the future of their clinical applications. Below are the finalists for the 2013 award.Click here to read and/or watch the interview with SCTM’s inaugural Young Investigator Award winner.

Special Neural Stem Cells Virtual Issue

Last updated:
28 December 2016
This special virtual issue highlights a number of exciting papers published in the Sister Journals over the past two years. By way of introduction, Professor Noel Buckley provides an insightful commentary on the burgeoning field of neural stem cells, focusing on their potential to improve our understanding of neurological disease and to reveal novel therapeutic targets. He goes on to discuss the huge challenges that remain in the design of relevant experimental systems.
The manuscripts selected from STEM CELLS and STEM CELLS Translational Medicine for this collection illustrate the novelty and diversity of experimental approaches to neurodevelopmental and neurodegenerative disorders currently underway globally.
We hope that you will be both informed and inspired by browsing this Virtual Issue!

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Early Results Show Irregular Heartbeat Improves After Mesenchymal Stem Cells Treatment

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