Alzheimer’s Disease: A Special Collection

A Note from Stuart P. Atkinson, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Epigenetic Architecture Group, Centro de Investigacion Principe Felipe, Valencia, Spain

This special collection of articles on Alzheimer’s disease (AD), previously published in STEM CELLS and STEM CELLS Translational Medicine, comes hot on the heels of new figures from the Centers for Disease Control and Prevention that indicate that the death rate from AD in the United States is slowly creeping up. The rise from 29 to 31 deaths per 100,000 people this past year will translate to thousands more deaths and vast amounts of additional health care costs with each passing year [1]. Furthermore, it is likely that statistics from other countries around the world will also display this same unfortunate trend.

However, as can be appreciated by the sheer number of high-quality studies, stem cell therapy may represent an important treatment option for AD and other dementia-related diseases and disorders. STEM CELLS and STEM CELLS Translational Medicine have held a long interest in potential stem cell therapies for AD, and we hope that you enjoy reading this excellent collection of 11 well-cited recent articles that encompass the breadth of research performed by stem cell scientists in the field.

We thank all of the authors for their commitment to their research and the Journals and look forward to publishing new research on furthering this progress.

1. Thielking M. Morning Rounds Tuesday, August 8, 2017: Alzheimer’s deaths are creeping up in number. Available at Accessed August 22, 2017.

Call for Papers

This fast-paced stem and regenerative medicine field calls for more pioneering progress. We invite authors to submit their original research papers on stem cell treatments for Alzheimer's disease and other related neurodegenerative disorders that may lead us closer to bona fide treatments and their clinical application. All articles are subject to peer review.

Featured Articles


Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

Jong Kil Lee, Hee Kyung Jin, Shogo Endo, Edward H. Schuchman, Janet E. Carter, Jae‐sung Bae 
STEM CELLS 2010; 28: 329-343, DOI: 10.1002/stem.277

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Ruxandra Dafinca, Jakub Scaber, Nida'a Ababneh, Tatjana Lalic, Gregory Weir, Helen Christian, Jane Vowles, Andrew G.L. Douglas, Alexandra Fletcher‐Jones, Cathy Browne, Mahito Nakanishi, Martin R. Turner, Richard Wade‐Martins, Sally A. Cowley, Kevin Talbot
First Published: 4 May 2016
STEM CELLS 2015; 34: 2063-2078, DOI: 10.1002/stem.2388

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult with Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration

Aoife Murray, Audrey Letourneau, Claudia Canzonetta, Elisavet Stathaki, Stefania Gimelli, Frederique Sloan‐Bena, Robert Abrehart, Pollyanna Goh, Shuhui Lim, Chiara Baldo, Franca Dagna‐Bricarelli, Saad Hannan, Martin Mortensen, David Ballard, Denise Syndercombe Court, Noemi Fusaki, Mamoru Hasegawa, Trevor G. Smart, Cleo Bishop, Stylianos E. Antonarakis, Jürgen Groet, Dean Nizetic
First Published: 21 May 2015
STEM CELLS 2015; 34: 2077-2084, DOI: 10.1002/stem.1968

Age-Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis

Hanadie Yousef, Adam Morgenthaler, Christina Schlesinger, Lukasz Bugaj, Irina M. Conboy, David V. Schaffer
STEM CELLS 2015; 34: 1577-1588, DOI: 10.1002/stem.1943

STEM CELLS Translational Medicine

Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction

Jordan A. Dykstra, Tiffany Facile, Ryan J. Patrick, Kevin R. Francis, Samuel Milanovich, Jill M. Weimer, Daniel J. Kota
STEM CELLS Translational Medicine 2017; 6: 1096-1108, DOI: 10.5966/sctm.2016-0337

Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease

Moon‐Yong Cha, Yoo‐Wook Kwon, Hyo‐Suk Ahn, Hyobin Jeong, Yong Yook Lee, Minho Moon, Sung Hoon Baik, Dong Kyu Kim, Hyundong Song, Eugene C. Yi, Daehee Hwang, Hyo‐Soo Kim, Inhee Mook‐Jung
STEM CELLS Translational Medicine 2017; 6: 293-305, DOI: 10.5966/sctm.2016-0081

Grafted Subventricular Zone Neural Stem Cells Display Robust Engraftment and Similar Differentiation Properties and Form New Neurogenic Niches in the Young and Aged Hippocampus

Ashok K. Shetty, Bharathi Hattiangady
STEM CELLS Translational Medicine 2016; 5: 1204–1215, DOI: 10.5966/sctm.2015-0270

Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease

Lisa M. McGinley, Erika Simms, J. Simon Lunn, Osama N. Kashlan, Kevin S. Chen, Elizabeth S. Bruno, Crystal M. Pacut, Tom Hazel, Karl Johe, Stacey A. Sakowski, Eva L. Feldman
STEM CELLS Translational Medicine 2016; 5: 379–391, DOI: 10.5966/sctm.2015-0103

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds that Protect Against Oxidative Stress

Natasha Thorne, Nasir Malik, Sonia Shah, Jean Zhao, Bradley Class, Francis Aguisanda, Noel Southall, Menghang Xia,  John C. McKew, Mahendra Rao, Wei Zheng 
STEM CELLS Translational Medicine 2016; 5: 613–627, DOI: 10.5966/sctm.2015-0170

Activation of Developmental Nuclear Fibroblast Growth Factor Receptor 1 Signaling and Neurogenesis in Adult Brain by α7 Nicotinic Receptor Agonist

Sridhar T. Narla, Ilona Klejbor, Barbara Birkaya, Yu-Wei Lee, Janusz Morys, Ewa K. Stachowiak, Dorota Prokop, Merouane Bencherif, Michal K. Stachowiak
STEM CELLS Translational Medicine 2013; 2: 776-788, DOI: 10.5966/sctm.2012-0103

Alzheimer's Research U.K.: Defeating Dementia Through Research

Eric Karran
STEM CELLS Translational Medicine 2012; 1: 449-450, DOI: 10.5966/sctm.2012-0049

Press Releases

Study Shows How Growth Factor Aids Stem Cells’ Ability to Regenerate Damaged Teeth

New Study May Lead to Speedy Recovery From Hip Fractures

Stem Cells May Help Improve Corneal Wound Healing


Article Scans

Video Highlights

Video abstract from Drs. Banerjee, Surendran, Bharti, Morishita, Varshney, and Pal on their recently published STEM CELLS paper entitled, "Long non-coding RNA RP11-380D23.2 drives distal-proximal patterning of the lung by regulating PITX2 expression." Read the paper here.

Video abstract from Drs. Sayed, Ospino, Himmati, Lee, Chanda, Mocarski, and Cooke on their recently published STEM CELLS paper entitled, "Retinoic Acid Inducible Gene 1 Protein (RIG1)-like Receptor Pathway is Required for Efficient Nuclear Reprogramming." Read the paper here.

Video Library