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STEM CELLS Translational Medicine

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Aryl hydrocarbon receptor controls skin homeostasis, regeneration, and hair follicle cycling by adjusting epidermal stem cell function

Graphic Abstract: Aryl hydrocarbon receptor controls skin homeostasis, regeneration, and hair follicle cycling by adjusting epidermal stem cell function

Eva María Rico-Leo, et al., STEM CELLS

Aryl hydrocarbon receptor (AhR) has novel roles in skin homeostasis, regeneration, and hair cycling by controlling epidermal stem cells (EpdSCs) functions. During hair growth, AhR deficiency delays entry into anagen likely through loss of the self-renewal capacity and multipotentiality of AhR−/− hair follicle EpdSCs. The authors reinforce the idea that AhR plays important roles in skin homeostasis and propose this receptor as a target for the treatment of cutaneous pathologies, skin lesions, and skin regeneration. The feasibility to manipulate the expression and/or activity of AhR in models that recapitulate the architecture of the epidermis provides an opportunity to validate selective molecular modulator useful in the treatment of skin pathologies.



The heterogeneity of megakaryocytes and platelets and implications for ex vivo platelet generation

Graphic Abstract: The heterogeneity of megakaryocytes and platelets and implications for ex vivo platelet generationCuicui Liu, et al., STEM CELLS Translational Medicine 

Megakaryocytes (MKs) and platelets have much more diverse functions than previously appreciated, but the exact molecular and cellular features underlying the diverse functions remain largely unclear. This review summarizes the current findings of the functional and developmental heterogeneity of MKs and its potential link with platelet heterogeneity, providing new insights into the ex vivo platelet generation from human pluripotent stem cells and the future clinical treatment of related diseases.



Human induced pluripotent stem cell‐derived macrophages ameliorate liver fibrosis

Lakshman image

Somayeh Pouyanfard, et al., STEM CELLS

Improved treatment for diseased or degenerated tissues and organs is greatly needed. These studies demonstrate the ability to efficiently derive macrophages from human induced pluripotent stem cells(iPSCs) with the ability to improve liver fibrosis in a mouse xenograft model. The present study enables clinical translation to use these iPSC-derived cells to better treat diverse fibrotic diseases.



Role of extracellular vesicles from adipose tissue- and bone marrow-mesenchymal stromal cells in endothelial proliferation and chondrogenesis

Bennstein imageCansu Gorgun, et al., STEM CELLS Translational Medicine

Mesenchymal stromal cells are a great source for regenerative medicine applications. Cells derived from different tissues might have distinctive characteristics. Many studies suggest a critical therapeutic role for extracellular vesicles secreted by stromal cells. The authors characterized extracellular vesicles isolated from two different sources (bone marrow, adipose tissue). Despite, minimal structural differences, the authors observed different functional effects during the differentiation and maturation of cartilage tissue. Therefore, a deep investigation of biological effects is essential before selecting the optimal extracellular vesicle-cell source to be used in specific therapeutic settings.


 

 

 

 

 

 

 

 

 

 

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