Journal list menu
STEM CELLS
STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. STEM CELLS welcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The journal covers all aspects of stem cells embryonic stem cells/induced pluripotent stem cells; tissue-specific stem cells; stem cell technology: epigenetics, genomics, proteomics, and metabonomics; cancer stem cells; translational and clinical research; and regenerative medicine.
Featured in STEM CELLS
Browse Articles
-
more >Open access
Low‐Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro
- Xavier Leveque
- Mazene Hochane
- Fanny Geraldo
- Solene Dumont
- Catherine Gratas
- Lisa Oliver
- Claire Gaignier
- Valérie Trichet
- Pierre Layrolle
- Dominique Heymann
- Olivier Herault
- François M. Vallette
- Christophe Olivier
- STEM CELLS
- 12 April 2019
Abstract
Mesenchymal stem cells (P3) after 21 days' exposure to mixture of pesticides showed some similarities with cells from prolonged culture (P14), but also with the mesenchymal stem cells of aged donors. Modification of metabolic markers for MDH1, GOT, and SIRT3, associated with physiological aging, altered active T‐cell regulation and cytokine production (interleukin‐10, interleukin‐6, CCL2, transforming growth factor‐β) define a modified functional profile with similarities to accelerated cellular aging process.
Intracellular Notch1 Signaling in Cancer‐Associated Fibroblasts Dictates the Plasticity and Stemness of Melanoma Stem/Initiating Cells
- STEM CELLS
- 2 April 2019
Abstract
Intracellular Notch1 signaling in cancer‐associated fibroblasts (CAFs) serves as a molecular switch, inversely controlling stromal regulation of the plasticity and stemness of melanoma stem/initiating cells (MICs) and thereby modulating melanoma heterogeneity and aggressiveness. Therapeutic activation of the Notch1 pathway in CAFs can control MIC plasticity and inhibit MIC‐mediated melanoma aggressiveness/metastasis.
Notch Signaling in Nestin‐Expressing Cells in the Bone Marrow Maintains Erythropoiesis via Macrophage Integrity
- Tatsuhiro Sakamoto
- Naoshi Obara
- Hidekazu Nishikii
- Takayasu Kato
- Luan Cao‐Sy
- Ryosuke Fujimura
- Hideo Yagita
- Mamiko Sakata‐Yanagimoto
- Satoru Takahashi
- Shigeru Chiba
- STEM CELLS
- 1 April 2019
Abstract
We showed that Notch signaling in Nestin‐expressing MSCs regulates erythroid differentiation in the BM. Disruption of Notch signaling in Nestin‐expressing MSCs induced the upregulation of interleukin‐6 (IL‐6) in central macrophages, and IL‐6 can cause the impairment of erythroid‐island‐forming capacity in central macrophages. The results suggest that the erythropoiesis in the BM is regulated by interaction between the central macrophages and Nestin‐expressing MSCs.
Inhibitor of Apoptosis Proteins Determine Glioblastoma Stem‐Like Cells Fate in an Oxygen‐Dependent Manner
- Aurélie Soubéran
- Jessica Cappaï
- Mathieu Chocry
- Christopher Nuccio
- Julie Raujol
- Carole Colin
- Daniel Lafitte
- Hervé Kovacic
- Véronique Quillien
- Nathalie Baeza‐Kallee
- Geneviève Rougon
- Dominique Figarella‐Branger
- Aurélie Tchoghandjian
- STEM CELLS
- 28 March 2019
Abstract
Summary of apoptosis inhibitor proteins inhibition effect depending on oxygen level in glioblastoma.
PDGF Signaling in Primitive Endoderm Cell Survival Is Mediated by PI3K‐mTOR Through p53‐Independent Mechanism
- STEM CELLS
- 26 March 2019
Abstract
Survival of primitive endoderm cells in the blastocyst embryo is mediated by PI3K/mTOR signaling pathway independently from p53. This activity is mainly driven by platelet‐derived growth factor receptor but not KIT or FGFR2 receptors. Lastly, LIF/JAK–STAT signaling cooperates with PDGF to regulate primitive endoderm cell survival.
Open accessConcise Review: Reduction of Adverse Cardiac Scarring Facilitates Pluripotent Stem Cell‐Based Therapy for Myocardial Infarction
- STEM CELLS
- 26 March 2019
Abstract
Implanted stem cells including pluripotent stem cell derivatives can invade fibrotic tissue through production of paracrine factors that degrade fibrillar collagens. Conversely, multiple factors (such as fragments of extracellular matrix, pro‐inflammatory cytokines, and mechanical signals) derived from fibrotic tissue can obstruct the migration and engraftment of implanted cells. In this review, we focus on the interaction between fibroblasts and stem cells, antifibrotic strategies, and stem cell‐based therapies for myocardial infarction.
Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach
- STEM CELLS
- 21 March 2019
Abstract
We present a simple mathematical model for the regulation of populations of murine hematopoietic stem cells (consisting of repopulating hematopoietic stem cells and maintaining hematopoietic stem cells) and progenitors. By assuming that repopulating hematopoietic stem cell proliferation is driven by downstream demand and by incorporating the ability of repopulating hematopoietic stem cells to divide asymmetrically, we are able to explain the observed aging‐related increase in repopulating hematopoietic stem cell numbers due to a decline in their capability to divide asymmetrically as well as recent experimental findings on specific depletion of hematopoietic stem and progenitor cells and their recovery. We further investigate the system reaction, if similar experiments are conducted in old mice.
Chromosome Transplantation: Correction of the Chronic Granulomatous Disease Defect in Mouse Induced Pluripotent Stem Cells
- Alessandra Castelli
- Lucia Susani
- Ciro Menale
- Sharon Muggeo
- Elena Caldana
- Dario Strina
- Barbara Cassani
- Camilla Recordati
- Eugenio Scanziani
- Francesca Ficara
- Anna Villa
- Paolo Vezzoni
- Marianna Paulis
- STEM CELLS
- 20 March 2019
Abstract
To correct genomic disorders due to chromosome abnormalities, the chromosome transplantation approach is proposed. As proof of principle, we applied this protocol to induced pluripotent stem cells derived from an X‐linked chronic granulomatous disease mouse model, showing that the chromosome transplanted corrected cells are able to rescue the functional defect in differentiated granulocytes.
free accessConcise Review: Targeting Cancer Stem Cells and their Supporting Niche Using Oncolytic Viruses
- STEM CELLS
- 15 March 2019
Abstract
Adipose‐Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor‐Mediated Transforming Growth Factor‐β Down Regulation and Recruitment of Bone Marrow Cells
- STEM CELLS
- 12 March 2019
Abstract
Mechanism of Adipose‐Derived Stem Cells Mitigation of Radiation‐Induced Fibrosis
Hepatocyte growth factor produced by adipose‐derived stem cells injected at the irradiated site mitigates radiation‐induced fibrosis. This is accomplished first by directly downregulating the expression of the profibrotic genes in damaged cells to stop the progression of the disease and secondly by recruiting bone marrow cells to regenerate damaged tissue.
-
more >
Newly defined ABCB5+ dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin‐1 receptor antagonist
- Seppe Vander Beken
- Juliane C. de Vries
- Barbara Meier‐Schiesser
- Patrick Meyer
- Dongsheng Jiang
- Anca Sindrilaru
- Filipa F. Ferreira
- Adelheid Hainzl
- Susanne Schatz
- Jana Muschhammer
- Natalie J. Scheurmann
- Panagiotis Kampilafkos
- Andreas M. Seitz
- Lutz Dürselen
- Anita Ignatius
- Mark A. Kluth
- Christoph Ganss
- Meinhard Wlaschek
- Karmveer Singh
- Pallab Maity
- Natasha Y. Frank
- Markus H. Frank
- Karin Scharffetter‐Kochanek
- STEM CELLS
- 19 April 2019
Abstract
In chronic wounds, M1 macrophages and their autocrine amplification of inflammasome‐generated IL‐1β perpetuates a pro‐inflammatory environment impeding the progression through normal phases of wound healing. IL‐1RA adaptively secreted by ABCB5+ MSCs when exposed to the M1 macrophage imprinted pro‐inflammatory wound environment, attenuates this vicious cycle and leads to a shift from pro‐inflammatory M1 toward anti‐inflammatory, wound healing‐promoting M2 macrophages as observed in normal wound healing.
Open accessp53‐TIGAR axis‐mediated glycolytic suppression attenuates DNA damage and genomic instability in Fanconi anemia hematopoietic stem cells
- STEM CELLS
- 12 April 2019
Abstract
p53‐TIGAR‐mediated glycolytic suppression attenuates ROS production, reduces DNA damage, ameliorates chromosomal instability, and consequently prevents premature exhaustion of FA HSCs.
free accessMesenchymal stem cells: from roots to boost
- STEM CELLS
- 12 April 2019
Abstract
Mesenchymal stem cells: from isolation to transplantation
Loss of the Heparan Sulfate Proteoglycan Glypican5 facilitates long‐range Shh signaling
- STEM CELLS
- 12 April 2019
Abstract
A: Under normal conditions the presentation of Shh to the surface of the Shh‐expressing cells is facilitated by HSPGs. However, HSPGs prevent widespread distribution of Shh away from the cell presumably by sequestration and endocytosis. B: The absence of HSPG form cells other than the Shh expressing cells results in local accumulation of Shh and an enhanced Shh response.
free accessTNF‐stimulated gene‐6 (TSG‐6) is a key regulator in switching stemness and biological properties of mesenchymal stem cells
- Barbara Romano
- Sudharshan Elangovan
- Marco Erreni
- Sala Emanuela
- Luciana Petti
- Paolo Kunderfranco
- Luca Massimino
- Silvia Restelli
- Shruti Sinha
- Donatella Lucchetti
- Achille Anselmo
- Federico Simone Colombo
- Matteo Stravalaci
- Vincenzo Arena
- Silvia D'Alessio
- Federica Ungaro
- Antonio Inforzato
- Angelo A. Izzo
- Alessandro Sgambato
- Anthony J Day
- Stefania Vetrano
- STEM CELLS
- 3 April 2019
Abstract
Loss of TSG‐6 in murine MSCs drives changes in cell morphology and actin‐cytoskeleton organization that ultimately impact cell proliferation and differentiation capacities of MSCs. It regulates the activities of transcription factors involved in several MSC cellular processes, crucial for the maintenance of stemness and biological properties. Its loss led to the abrogation of immunomodulatory properties and stemness capacities conferring to MSCs a pro‐tumorigenic phenotype by an increased capacity to release IL‐6.
CRISPR‐KO screen identifies Dmap1 as a regulator of chemically‐induced reprogramming and differentiation of cardiac progenitors
- Jason S. L. Yu
- Giorgia Palano
- Cindy Lim
- Aldo Moggio
- Lauren Drowley
- Alleyn T. Plowright
- Mohammad Bohlooly‐Y
- Barry S. Rosen
- Emil M. Hansson
- Qing‐Dong Wang
- Kosuke Yusa
- STEM CELLS
- 1 April 2019
Abstract
Chemically‐induced reprogramming using Alk5i coupled with hypoxia permits the conversion of CF into CP which can spontaneously give rise to CM and EC. Enrichment for proliferative cells leads to the derivation of ciSMP which can give rise to myofibroblasts and SM. Modulation of Dmap1 enhances ciSMP derivation and self‐renewal but compromises differentiation potency via modulation of Cdh1.Open accessBmi1 Overexpression in Mesenchymal Stem Cells Exerts Anti‐Aging and Anti‐Osteoporosis Effects by Inactivating p16/p19 Signaling And Inhibiting Oxidative Stress
- STEM CELLS
- 20 March 2019
Abstract
Bmi1 overexpression in mesenchymal stem cells (MSCs) can inactivate p16/p19 signaling and inhibit oxidative stress, stimulate MSC proliferation and differentiation into osteoblasts, subsequently, enhance osteoblastic bone formation to exert an against osteoporosis role.
-
more >free access
Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue
- STEM CELLS
- 1294-1301
- 2 January 2009
free accessConcise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
- STEM CELLS
- 2739-2749
- 2 January 2009
free accessMesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
- STEM CELLS
- 2648-2659
- 2 January 2009
free accessConcise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
- STEM CELLS
- 2896-2902
- 2 January 2009
free accessIntra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
- Chris Hyunchul Jo
- Young Gil Lee
- Won Hyoung Shin
- Hyang Kim
- Jee Won Chai
- Eui Cheol Jeong
- Ji Eun Kim
- Hackjoon Shim
- Ji Sun Shin
- Il Seob Shin
- Jeong Chan Ra
- Sohee Oh
- Kang Sup Yoon
- STEM CELLS
- 1254-1266
- 21 January 2014
free accessExosome‐Mediated Transfer of miR‐133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth
- Hongqi Xin
- Yi Li
- Ben Buller
- Mark Katakowski
- Yi Zhang
- Xinli Wang
- Xia Shang
- Zheng Gang Zhang
- Michael Chopp
- STEM CELLS
- 1556-1564
- 17 May 2012
free accessRole for Interferon‐γ in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells
- Mauro Krampera
- Lorenzo Cosmi
- Roberta Angeli
- Annalisa Pasini
- Francesco Liotta
- Angelo Andreini
- Veronica Santarlasci
- Benedetta Mazzinghi
- Giovanni Pizzolo
- Fabrizio Vinante
- Paola Romagnani
- Enrico Maggi
- Sergio Romagnani
- Francesco Annunziato
- STEM CELLS
- 386-398
- 2 January 2009
free accessConcise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- STEM CELLS
- 1408-1419
- 28 February 2014
free accessConcise Review: MSC‐Derived Exosomes for Cell‐Free Therapy
- STEM CELLS
- 851-858
- 10 March 2017
-
free access
Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue
- STEM CELLS
- 1294-1301
- 2 January 2009
free accessConcise Review: MSC‐Derived Exosomes for Cell‐Free Therapy
- STEM CELLS
- 851-858
- 10 March 2017
free accessConcise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- STEM CELLS
- 1408-1419
- 28 February 2014
free accessIntra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
- Chris Hyunchul Jo
- Young Gil Lee
- Won Hyoung Shin
- Hyang Kim
- Jee Won Chai
- Eui Cheol Jeong
- Ji Eun Kim
- Hackjoon Shim
- Ji Sun Shin
- Il Seob Shin
- Jeong Chan Ra
- Sohee Oh
- Kang Sup Yoon
- STEM CELLS
- 1254-1266
- 21 January 2014
free accessBone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications
- STEM CELLS
- 180-192
- 1 January 2009
free accessConcise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
- STEM CELLS
- 2739-2749
- 2 January 2009
free accessMesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
- STEM CELLS
- 2648-2659
- 2 January 2009
free accessConcise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
- STEM CELLS
- 2896-2902
- 2 January 2009
Open accessConcise Review: Human Embryonic Stem Cells—What Have We Done? What Are We Doing? Where Are We Going?
- STEM CELLS
- 17-25
- 28 June 2016
Abstract
Ethical issues, the regulatory landscape, and the limited spectrum of diseases were all drawbacks of hESC lines that hiPSC did not have. It is to expect that in foreseeable future hiPSC will take over hESC in both research and clinical applications.
Open accessHuman‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency
- Dean Hallam
- Gerrit Hilgen
- Birthe Dorgau
- Lili Zhu
- Min Yu
- Sanja Bojic
- Philip Hewitt
- Michael Schmitt
- Marianne Uteng
- Stefan Kustermann
- David Steel
- Mike Nicholds
- Robert Thomas
- Achim Treumann
- Andrew Porter
- Evelyne Sernagor
- Lyle Armstrong
- Majlinda Lako
- STEM CELLS
- 1535-1551
- 13 July 2018
Abstract
Five iPSC lines differentiated to light responsive retinal organoids with variable efficiency. Seeding density and nutrient availability had the most dominant effect on retinal organoid formation. Using a high‐throughput compatible multiwell format, we showed that drug testing is compatible with this system.
Tools
Journal Features
Journal Resources
Advertisement
Press Releases
Stay Connected
News
Article Scans
Video Highlights
Lab Video from STEM CELLS 2018 Young Investigator Benjamin “Beno” Freedman, Ph.D., for his groundbreaking work with organoids in studying kidney structure and disease. His paper “Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development,” can be read here.
Download the app
Download the STEM CELLS app from the Apple store
New Android App Available!
Download the STEM CELLS app from the Google Play Store
