STEM CELLS
STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. STEM CELLS welcomes original articles and concise reviews describing basic laboratory investigations of stem cells and the translation of their clinical aspects of characterization and manipulation from the bench to patient care. The journal covers all aspects of stem cells embryonic stem cells/induced pluripotent stem cells; tissue-specific stem cells; stem cell technology: epigenetics, genomics, proteomics, and metabonomics; cancer stem cells; translational and clinical research; and regenerative medicine.
Featured in STEM CELLS
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Cord Blood‐Derived Stem Cells Suppress Fibrosis and May Prevent Malignant Progression in Recessive Dystrophic Epidermolysis Bullosa
- Yanling Liao
- Larisa Ivanova
- Hongwen Zhu
- Trevor Plumer
- Carl Hamby
- Brinda Mehta
- Annie Gevertz
- Angela M. Christiano
- John A. McGrath
- Mitchell S. Cairo
- STEM CELLS
- 24 September 2018
Abstract
This study demonstrates the dual effects of USSCs on modulating RDEB skin microenvironment. USSCs exert anti‐fibrotic function by suppressing phosphorylation of Smad2/3 in the fibroblasts (Fb) and macrophages (MΦ) of the skin, inhibiting MMP‐9 and MMP‐13 dermal expression and upregulating anti‐fibrotic TGFβ3 and DCN expression. USSCs also attenuate secretion of MMP‐9 and MMP‐13, which correlate with epithelial malignant transformation, from keratinocytes (Kc) and cSCCs derived from patients with RDEB.
free accessA Preview of Selected Articles ‐ October 2018
- STEM CELLS
- 11 September 2018
free accessSpecial Series: Transplantation of Stem Cells into the Eye
- STEM CELLS
- 22 August 2018
c‐MPL Is a Candidate Surface Marker and Confers Self‐Renewal, Quiescence, Chemotherapy Resistance, and Leukemia Initiation Potential in Leukemia Stem Cells
- Huan Li
- Na Zhao
- Yihui Li
- Haiyan Xing
- Shuying Chen
- Yingxi Xu
- Kejing Tang
- Zheng Tian
- Min Wang
- Qing Rao
- Jianxiang Wang
- STEM CELLS
- 14 August 2018
Abstract
In this study, application of chemotherapy treatment in AML‐ETO9a leukemia mice led to the enrichment of a chemotherapy‐resistant cell population identified as Lin‐c‐Kit+c‐MPL+. This c‐MPL‐positive cell population within Lin‐c‐Kit+ leukemia cells included a high percentage of cells in a quiescent state, enhanced colony formation ability and high potential for leukemia initiation. The results indicate that c‐MPL is a candidate leukemia stem cell (LSC) surface marker that may serve as a therapeutic target for the elimination of LSCs.
Open accessP2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis
- Hannah C. Leeson
- Maria A. Kasherman
- Tailoi Chan‐Ling
- Michael D. Lovelace
- Jeremy C. Brownlie
- Kelly M. Toppinen
- Ben J. Gu
- Michael W. Weible
- STEM CELLS
- 1 August 2018
Abstract
We demonstrate P2X7 could have multiple roles in adult neurogenesis. As a calcium channel, P2X7 signaling may negatively regulate neural progenitor cell proliferation, whereas retaining its canonical role as a death receptor via the formation of transmembrane pores. P2X7 may also contribute to niche maintenance by facilitating phagocytosis of apoptotic cells. This has implications for neurogenesis given the presence of inflammation and extracellular ATP.
Open accessIntravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single‐Blind, Parallel Group, Placebo Controlled Trial
- Desiree Perlee
- Lonneke A. van Vught
- Brendon P. Scicluna
- Anja Maag
- René Lutter
- Elles M. Kemper
- Cornelis van ‘t Veer
- Marie A. Punchard
- Jesús González
- Marie Paule Richard
- Wilfried Dalemans
- Eleuterio Lombardo
- Alex F. de Vos
- Tom van der Poll
- STEM CELLS
- 31 July 2018
Abstract
To explore the use of MSCs in sepsis, we determined their effect on the response to intravenous LPS in a randomized study in 32 healthy subjects with four treatment arms: placebo or allogeneic adipose MSCs (ASCs) intravenously at either 0.25 × 106, 1 × 106, or 4 × 106 cells/kg; all subjects received LPS intravenously (2 ng/kg) one hour after the end of ASC infusion. Primary endpoints included clinical signs and symptoms, leukocyte activation, cytokine release, activation of coagulation and vascular endothelium, genome‐wide mRNA expression profiles, and ex vivo responsiveness of blood leukocytes.
Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function
- Kristina Probst
- Jacek Stermann
- Inga Bomhard
- Julia Etich
- Lena Pitzler
- Anja Niehoff
- Björn Bluhm
- Haifeng C. Xu
- Philipp A. Lang
- Markus Chmielewski
- Hinrich Abken
- Birgit Blissenbach
- Alzbeta Machova
- Nikoletta Papadopoulou
- Bent Brachvogel
- STEM CELLS
- 31 July 2018
Abstract
Consequences of collagen IX depletion for trabecular bone organization and myeloid cell differentiation and function
Open accessRepurposing the Cord Blood Bank for Haplobanking of HLA‐Homozygous iPSCs and Their Usefulness to Multiple Populations
- Suji Lee
- Ji Young Huh
- David M. Turner
- Soohyeon Lee
- James Robinson
- Jeremy E. Stein
- Sung Han Shim
- Chang Pyo Hong
- Myung Seo Kang
- Masato Nakagawa
- Shin Kaneko
- Mahito Nakanishi
- Mahendra S. Rao
- Andreas Kurtz
- Glyn N. Stacey
- Steven G.E. Marsh
- Marc L. Turner
- Jihwan Song
- STEM CELLS
- 13 July 2018
Abstract
By repurposing the existing cord blood bank, we established 10 most frequent HLA‐homozygous iPSC lines from the Korean population. Comparative HLA analysis indicates that they are relevant to multiple populations including Japan and the UK. This study highlights the importance of collaborative HLA driven selection of donors for future stocking of worldwide iPSC haplobanks.
The Adaptive Remodeling of Stem Cell Niche in Stimulated Bone Marrow Counteracts the Leukemic Niche
- STEM CELLS
- 13 July 2018
Abstract
Adaptive switching of BM mesenchymal cells between positive and negative niche. Stimulated mesenchymal cells undergo a non‐mitotic adaptive conversion into niche‐like (PL) cells, acquiring primitive mesenchymal phenotype. PL cells induce Jagged‐1 for regeneration of HSCs, but suppression of leukemic cells. The pronormal/antileukemic microenvironment (positive) acquired by stimulation can counteract the degenerative negative microenvironment (proleukemic/antinormal) induced by leukemic niche.
Open accessHuman‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency
- Dean Hallam
- Gerrit Hilgen
- Birthe Dorgau
- Lili Zhu
- Min Yu
- Sanja Bojic
- Philip Hewitt
- Michael Schmitt
- Marianne Uteng
- Stefan Kustermann
- David Steel
- Mike Nicholds
- Robert Thomas
- Achim Treumann
- Andrew Porter
- Evelyne Sernagor
- Lyle Armstrong
- Majlinda Lako
- STEM CELLS
- 13 July 2018
Abstract
Five iPSC lines differentiated to light responsive retinal organoids with variable efficiency. Seeding density and nutrient availability had the most dominant effect on retinal organoid formation. Using a high‐throughput compatible multiwell format, we showed that drug testing is compatible with this system.
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Re: “Concise Review: The Effect of Low‐Dose Ionizing Radiation on Stem Cell Biology: A Contribution to Radiation Risk”
- STEM CELLS
- 1 September 2018
free accessReply to comments on “Concise Review: The Effect of Low‐Dose Ionizing Radiation on Stem Cell Biology: A Contribution to Radiation Risk”
- STEM CELLS
- 1 September 2018
free accessTLR pathway‐miRNA interplay in mesenchymal stromal cells: Regulatory roles and therapeutic directions
- STEM CELLS
- 1 September 2018
Abstract
TLR pathways‐microRNA interplay in MSCs affects the phenotype of MSCs and the interacting microenvironment including immune cells. TLR‐responding microRNA may also transfer to the new cells via extracellular vesicles released by MSCs.
LncRNA WTAPP1 promotes migration and angiogenesis of endothelial progenitor cells via MMP1 through microRNA 3,120 and Akt/PI3K/autophagy pathways
- STEM CELLS
- 1 September 2018
Abstract
The lncRNA WTAPP1, a molecular decoy for miR‐3,120‐5p, regulates MMP‐1 expression via the PI3K/Akt and autophagy pathways, thereby mediating cell migration and angiogenesis in EPCs.
Regulation of human airway epithelial tissue stem cell differentiation by β‐catenin, P300, and CBP
- STEM CELLS
- 1 September 2018
Abstract
This study indicates that activation of β‐catenin dependent signaling in chronic lung disease leads to changes in mucus and ciliated cell frequency and that P300 and CBP tune the β‐catenin signal to favor mucus cell differentiation.
Barrier properties and transcriptome expression in human iPSC‐derived models of the blood–brain barrier
- Louise Delsing
- Pierre Dönnes
- José Sánchez
- Maryam Clausen
- Dimitrios Voulgaris
- Anna Falk
- Anna Herland
- Gabriella Brolén
- Henrik Zetterberg
- Ryan Hicks
- Jane Synnergren
- STEM CELLS
- 1 September 2018
Abstract
Human induced pluripotent stem cells (iPSCs) can be used to generate relevant cell types to model the BBB with human tissue. We generated a human iPSC‐derived model of the BBB that includes endothelial cells in co‐culture with pericytes, astrocytes and neurons. Evaluation of barrier properties and whole genome transcription analysis showed improved BBB modeling in the co‐cultures. Co‐cultured endothelial cells have high transendothelial electrical resistance, functional efflux, ability to discriminate between CNS permeable and non‐permeable substances and upregulation of brain specific transporters.
Chromatin remodeling factor BRG1 regulates stemness and chemosensitivity of glioma initiating cells
- STEM CELLS
- 1 September 2018
Abstract
BRG1 maintains stemness in GICs. BRG1 is essential for maintaining GICs in a stem‐like state. BRG1 negatively regulates TXNIP expression in GICs and thereby promotes the expression of genes involved in glycolysis, which is a pathway critical in cancer metabolism. In addition, BRG1 also promotes GIC chemoresistance by modulating MGMT expression. In GICs, the loss of BRG1 leads to increased TXNIP expression, consequently decreasing the expression of glycolytic genes. BRG1 loss in GICs also decreases GIC stemness and leads to lineage specific differentiation. In addition, loss of BRG1 leads to decreased MGMT expression and thereby enhances GIC chemosensitivity.
free accessHeart‐Derived Cell Therapy 2.0: Paracrine strategies to increase therapeutic repair of injured myocardium
- STEM CELLS
- 1 September 2018
Abstract
CD200 expression marks a population of quiescent limbal epithelial stem cells with holoclone forming ability
- Sanja Bojic
- Dean Hallam
- Nuno Alcada
- Ali Ghareeb
- Rachel Queen
- Sagoo Pervinder
- Harley Buck
- Aya Amitai Lange
- Gustavo Figueiredo
- Paul Rooney
- Miodrag Stojkovic
- Alex Shortt
- Francisco C. Figueiredo
- Majlinda Lako
- STEM CELLS
- 29 August 2018
Abstract
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Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue
- STEM CELLS
- 1294-1301
- 2 January 2009
free accessConcise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
- STEM CELLS
- 2739-2749
- 2 January 2009
free accessMesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
- STEM CELLS
- 2648-2659
- 2 January 2009
free accessConcise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
- STEM CELLS
- 2896-2902
- 2 January 2009
free accessRole for Interferon‐γ in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells
- Mauro Krampera
- Lorenzo Cosmi
- Roberta Angeli
- Annalisa Pasini
- Francesco Liotta
- Angelo Andreini
- Veronica Santarlasci
- Benedetta Mazzinghi
- Giovanni Pizzolo
- Fabrizio Vinante
- Paola Romagnani
- Enrico Maggi
- Sergio Romagnani
- Francesco Annunziato
- STEM CELLS
- 386-398
- 25 August 2005
free accessIntra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
- Chris Hyunchul Jo
- Young Gil Lee
- Won Hyoung Shin
- Hyang Kim
- Jee Won Chai
- Eui Cheol Jeong
- Ji Eun Kim
- Hackjoon Shim
- Ji Sun Shin
- Il Seob Shin
- Jeong Chan Ra
- Sohee Oh
- Kang Sup Yoon
- STEM CELLS
- 1254-1266
- 21 January 2014
free accessMesenchymal Stem Cells in the Wharton's Jelly of the Human Umbilical Cord
- Hwai‐Shi Wang
- Shih‐Chieh Hung
- Shu‐Tine Peng
- Chun‐Chieh Huang
- Hung‐Mu Wei
- Yi‐Jhih Guo
- Yu‐Show Fu
- Mei‐Chun Lai
- Chin‐Chang Chen
- STEM CELLS
- 1330-1337
- 23 December 2008
free accessConcise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- STEM CELLS
- 1408-1419
- 28 February 2014
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Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue
- STEM CELLS
- 1294-1301
- 2 January 2009
free accessConcise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- STEM CELLS
- 1408-1419
- 28 February 2014
free accessIntra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
- Chris Hyunchul Jo
- Young Gil Lee
- Won Hyoung Shin
- Hyang Kim
- Jee Won Chai
- Eui Cheol Jeong
- Ji Eun Kim
- Hackjoon Shim
- Ji Sun Shin
- Il Seob Shin
- Jeong Chan Ra
- Sohee Oh
- Kang Sup Yoon
- STEM CELLS
- 1254-1266
- 21 January 2014
free accessBone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications
- STEM CELLS
- 180-192
- 1 January 2009
free accessConcise Review: MSC‐Derived Exosomes for Cell‐Free Therapy
- STEM CELLS
- 851-858
- 10 March 2017
free accessConcise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
- STEM CELLS
- 2739-2749
- 2 January 2009
Open accessNotch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells
- Amy Leung
- Elizabeth Zulick
- Nicholas Skvir
- Kim Vanuytsel
- Tasha A. Morrison
- Zaw Htut Naing
- Zhongyan Wang
- Yan Dai
- David H. K. Chui
- Martin H. Steinberg
- David H. Sherr
- George J. Murphy
- STEM CELLS
- 1004-1019
- 23 March 2018
Abstract
A chemically defined platform for the generation of hematopoietic stem‐progenitor cells and resultant adult‐type blood cells from human induced pluripotent stem cells via the stage‐specific modulation of the Notch and aryl hydrocarbon receptor pathways.
free accessConcise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
- STEM CELLS
- 2896-2902
- 2 January 2009
free accessMesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
- STEM CELLS
- 2648-2659
- 2 January 2009
Open accessIsolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell‐Derived Retinal Organoids and Fetal Retinae
- Jörn Lakowski
- Emily Welby
- Dimitri Budinger
- Fabiana Di Marco
- Valentina Di Foggia
- James W.B. Bainbridge
- Kyle Wallace
- David M. Gamm
- Robin R. Ali
- Jane C. Sowden
- STEM CELLS
- 709-722
- 12 January 2018
Abstract
Cell surface (cluster of differentiation markers; CD) markers expressed on human retinal cells were identified using BD lyoplate antibody screening panels. Fluorescence‐activated cell sorting (FACS) and CD marker antibodies were used to purify photoreceptor cells from dissociated human pluripotent stem cell (hPSC)‐derived retinal organoids and fetal retinae. Purified human photoreceptor cells are useful for cell therapy and study of retinal disease.
