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STEM CELLS
STEM CELLS focuses primarily on the functional and mechanistic aspects of stem cell biology and the potential of different types of stem cells for therapeutic applications. The journal publishes key, well-controlled advances in stem cell clinical trials and mechanism-based manuscripts with definitive conclusions.
Featured in STEM CELLS
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PKCβ-Dependent Metabolic Changes on BMSC
Here, the authors can show for the first time a link between stromal metabolism and PKCβ expression in BMSC after contact to primary chronic lymphocytic leukemia cells.
Spinal Cord MBP Regulates Stem Cells
This study shows that myelin basic protein (MBP), a major constituent of myelin sheaths in the CNS, regulates NPC behavior in a niche dependent fashion.
Browse Articles
Open access
Bone‐forming perivascular cells: Cellular heterogeneity and use for tissue repair
Jiajia Xu, Yiyun Wang, Mario A. Gomez-Salazar, Ginny Ching-Yun Hsu, Stefano Negri, Zhao Li, Winters Hardy, Lijun Ding, Bruno Peault, Aaron W. James,
- 12 July 2021
Abstract
Mesenchymal progenitor cells in the tunica adventitia have a hierarchy of differentiation and proliferation potential. On top of the hierarchy, platelet-derived growth factor receptor (PDGFR)α+ and aldehyde dehydrogenase (ALDH)High cells show a bipotent differentiation potential into osteogenic and adipogenic cell lineages with high proliferative rate. Conversely, CD10 and CD107a expression separate osteogenic progenitors from adipogenic progenitors, respectively. Moreover, osteoprogenitors can transition into adipogenic phenotype.
Hematopoietic stem cell‐derived functional osteoblasts exhibit therapeutic efficacy in a murine model of Osteogenesis imperfecta
In-Hong Kang, Uday K. Baliga, Yongren Wu, Shikhar Mehrotra, Hai Yao, Amanda C. LaRue, Meenal Mehrotra,
- 5 July 2021
Abstract
Transplantation (Tp) of hematopoietic stem cells (HSCs) in Osteogenesis imperfecta (OI) mice causes replacement of mutated osteoblasts with normal osteoblasts (derived from HSCs) that lay down normal collagen and result in clinical improvements.
Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis‐related genes in mouse embryonic stem cells
Kousuke Uranishi, Masataka Hirasaki, Yuka Kitamura, Yosuke Mizuno, Masazumi Nishimoto, Ayumu Suzuki, Akihiko Okuda,
- 5 July 2021
Abstract
MGA bearing two distinct DNA-binding domains is a scaffolding component of PRC1.6 that prevents precocious and ectopic onset of meiosis in germ cells and embryonic stem cells (ESCs), respectively. Here, we demonstrate that both Mga domains repress distinct sets of meiosis-related genes in ESCs. Our data also identified Meiosin as a linchpin molecule between positive and negative regulations of meiotic onset.
Cytokine and epigenetic regulation of programmed death‐ligand 1 in stem cell differentiation and cancer cell plasticity
Ming-Han Kuo, Pei-Yu Chen, Yi-Ping Yang, Ming-Yi Zheng, Chia-Cheng Miao, Kuo-Chang Wen, Kuo-Ming Chang, Shih-Jie Chou, Mong-Lien Wang, Shih-Hwa Chiou, Yu-Ting Chou,
- 28 June 2021
Abstract
SOX2-mediated reprogramming of fibroblasts or cancer plasticity of lung cancer cells inhibits programmed death-ligand 1 (PD-L1) expression (upper). SOX2 expression is negatively associated with PD-L1 as well as HBEGF/EGFR and TGF-β signaling molecules (middle). SOX2 interacts with HDAC1, which silences PD-L1 expression (lower left). TGF-β induces PD-L1 expression via MEK pathway, while HBEGF/EGFR enhances PD-L1 expression through MEK and AKT pathways (lower right).
Open access
DUSP5 promotes osteogenic differentiation through SCP1/2‐dependent phosphorylation of SMAD1
Xuejiao Liu, Xuenan Liu, Yangge Du, Menglong Hu, Yueming Tian, Zheng Li, Longwei Lv, Xiao Zhang, Yunsong Liu, Yongsheng Zhou, Ping Zhang,
- 24 June 2021
Abstract
DUSP5 promotes the osteogenic differentiation of mesenchymal stromal cells (MSCs) by repressing SMAD1 signaling pathway in a SCP1/2-dependent manner. The linker region of DUSP5 occupies the phosphatase domain of SCP1/2 and thereby releases the inhibitory effect of SCP1/2 on SMAD1 signaling. Additionally, Dusp5 overexpression could effectively ameliorate osteopenia of mice.
Open access
SARS‐CoV‐2 infects an upper airway model derived from induced pluripotent stem cells
Ivo Djidrovski, Maria Georgiou, Grant L. Hughes, Edward I. Patterson, Aitor Casas-Sanchez, Shaun H. Pennington, Giancarlo A. Biagini, Marina Moya-Molina, Jelle van den Bor, Martine J. Smit, Git Chung, Majlinda Lako, Lyle Armstrong,
- 21 June 2021
Abstract
We have developed a protocol to generate airway epithelial basal-like cells from induced pluripotent stem cells, which simplifies the manufacture of cellular models of the human upper airways that are capable of supporting SARS-CoV-2 infection/replication and the secretion of cytokines in a manner similar to that of in vivo airways.
Open access
Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme‐2 and masR receptor‐dependent
Mansoureh Barzegar, Shantel Vital, Karen Y. Stokes, Yuping Wang, Jungmi Winny Yun, Luke A. White, Oleg Chernyshev, Roger E. Kelley, Jonathan S. Alexander,
- 14 June 2021
Abstract
Angiotensin converting enzyme-2 (ACE-2) contributes to human placenta mesenchymal stem cell (hPMSC)-induced protection against ischemic injury through MasR pathway.
Open access
Mitochondria in neurogenesis: Implications for mitochondrial diseases
- 5 June 2021
Abstract
During healthy neurogenesis, there is an orchestrated programming of energy metabolism, which transits from glycolysis toward oxidative phosphorylation (OXPHOS). In mitochondrial diseases, neural progenitor cells (NPCs) may fail to acquire an OXPHOS profile, leading to impaired generation and maturation of neurons. NPC metabolism may thus represent a potential target of interventions for mitochondrial neurological diseases.
Open access
Zbtb46‐dependent altered developmental program in embryonic stem cell‐derived blood cell progenitors
- 31 May 2021
Abstract
In this study, we engineered murine Zbtb46-inducible embryonic stem cell lines and characterize their hematopoietic differentiation capacity. We found here that enforced expression of Zbtb46 strongly suppressed the myeloid blood cell development; moreover, this transcription factor negatively influenced the cell proliferation. On the other hand, ectopic expression of Zbtb46 was coupled with the enhanced production of CD105+ cells and the augmented erythroid blood cell development.
Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress
Joshua Tay, Valerie Barbier, Falak M. Helwani, Gareth R. Price, Jean-Pierre Levesque, Ingrid G. Winkler,
- 14 July 2021
Abstract
Prostacyclin/prostaglandin I2 (PGI2) is a novel hematopoietic stem cell (HSC) regulatory factor enriched at the endosteum, synthesized by its synthase PTGIS expressed mainly on osteoblasts (OB), followed by mesenchymal stromal cells (MSC) and endothelial cells (EC). Ex vivo and in vivo treatment with PGI2 analogues enhance HSC long-term competitive repopulation potential and protect reconstituting HSC from stress.
Open access
Human multipotent adult progenitor cells effectively reduce graft‐vs‐host disease while preserving graft‐vs‐leukemia activity following experimental, allogeneic bone marrow transplantation
Leland Metheny MD, Saada Eid BS MBA, Patiwet Wuttisarnwattana PhD, Jeffery J Auletta MD, Chen Liu, Alana Van Dervort BS, Conner Paez BA, Zheng Hong Lee PhD, David Wilson PhD, Hillard M Lazarus, Robert Deans PhD, Vant Hof Wouter PhD, Yiouli Ktena MD, Kenneth R Cooke MD,
- 13 July 2021
Abstract
Bio-redistribution of MAPC cells from the lung and to the liver and spleen of allogeneic BMT recipient mice as captured by 3-D, computer-generated imagery.
Bone marrow‐derived progenitor cells contribute to remodeling of the postpartum uterus
Reshef Tal, Jacqueline Kisa, Nafeesa Abuwala, Harvey J. Kliman, Shafiq Shaikh, Alice Y. Chen, Fang Lyu, Hugh S. Taylor,
- 5 July 2021
Abstract
Bone marrow-derived stem cells (BMDSC) are mobilized to the circulation and get recruited to the uterus in the postpartum period where they contribute to various nonhematopoietic endometrial cell populations as part of the process of cellular turnover and regeneration. They differentiate into stromal cells, endothelial cells (EC) and epithelial cells, actively participating in uterine tissue remodeling.
free access
Organoid Technology: Current Standing and Future Perspectives
- 30 March 2021
Abstract
Organoid generation and therapeutic potential
free access
Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue
- STEM CELLS
- 1294-1301
- 2 January 2009
free access
Concise Review: MSC‐Derived Exosomes for Cell‐Free Therapy
- STEM CELLS
- 851-858
- 10 March 2017
free access
Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
- STEM CELLS
- 2739-2749
- 2 January 2009
free access
Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- STEM CELLS
- 1408-1419
- 28 February 2014
free access
Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
- STEM CELLS
- 2648-2659
- 2 January 2009
free access
Exosome‐Mediated Transfer of miR‐133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth
Hongqi Xin, Yi Li, Ben Buller, Mark Katakowski, Yi Zhang, Xinli Wang, Xia Shang, Zheng Gang Zhang, Michael Chopp,
- STEM CELLS
- 1556-1564
- 17 May 2012
free access
Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
Chris Hyunchul Jo, Young Gil Lee, Won Hyoung Shin, Hyang Kim, Jee Won Chai, Eui Cheol Jeong, Ji Eun Kim, Hackjoon Shim, Ji Sun Shin, Il Seob Shin, Jeong Chan Ra, Sohee Oh, Kang Sup Yoon,
- STEM CELLS
- 1254-1266
- 21 January 2014
free access
Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
- STEM CELLS
- 2896-2902
- 2 January 2009
free access
MiR‐133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome‐Enriched Extracellular Particles
Hongqi Xin, Yi Li, Zhongwu Liu, Xinli Wang, Xia Shang, Yisheng Cui, Zheng Gang Zhang, Michael Chopp,
- STEM CELLS
- 2737-2746
- 30 April 2013
free access
Concise Review: MSC‐Derived Exosomes for Cell‐Free Therapy
- STEM CELLS
- 851-858
- 10 March 2017
free access
Concise Review: Mesenchymal Stem Cells: From Roots to Boost
- STEM CELLS
- 855-864
- 12 April 2019
Abstract
Mesenchymal stem cells: from isolation to transplantation.
free access
A Review of the Costs, Cost‐Effectiveness and Third‐Party Charges of Bone Marrow Transplantation
- STEM CELLS
- 312-319
- May 1996
free access
Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- STEM CELLS
- 1408-1419
- 28 February 2014
Open access
Pluripotent stem cell‐derived retinal organoids for disease modeling and development of therapies
- STEM CELLS
- 1206-1215
- 7 June 2020
Abstract
Retinal organoids offer a unique human model system to study mechanisms of disease pathogenesis and for developing therapies.
free access
Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
Chris Hyunchul Jo, Young Gil Lee, Won Hyoung Shin, Hyang Kim, Jee Won Chai, Eui Cheol Jeong, Ji Eun Kim, Hackjoon Shim, Ji Sun Shin, Il Seob Shin, Jeong Chan Ra, Sohee Oh, Kang Sup Yoon,
- STEM CELLS
- 1254-1266
- 21 January 2014
free access
Distinct Roles for Wnt‐4 and Wnt‐11 During Retinoic Acid‐Induced Neuronal Differentiation
Carina Elizalde, Victor M. Campa, Mercedes Caro, Karin Schlangen, Ana María Aransay, Maria dM Vivanco, Robert M. Kypta,
- STEM CELLS
- 141-153
- 23 November 2010
free access
Restoring aged stem cell functionality: Current progress and future directions
- STEM CELLS
- 1060-1077
- 30 May 2020
Abstract
Possibly, combination of treatments may allow for more universal benefits encompassing many stem cell compartments.
free access
Stem cell homing: From physiology to therapeutics
- STEM CELLS
- 1241-1253
- 11 June 2020
Abstract
Steps in hematopoietic stem cell (HSC) homing and egress to and from marrow. Homing (left hand panel) occurs in the marrow sinusoidal endothelium. (1) Selectin-mediated braking or rolling occurs. Selectins involved include P-selectin which interacts with CD162 and SLex, and E-selectin which recognizes CD15, SLex, and CD162 on stem cells. (2) HSCs migrate on adhesion ligands presented by the vascular endothelium, so-called tethering. This involves CD49d-f, CD11b, and CD11c on the hematopoietic stem and progenitor cells and CD106/fibronectin, laminin, and ICAM-1 on endothelium as well as numerous other adhesion receptors and their ligands. (3) Changes in integrin conformation facilitate tight adhesion to the endothelial cell. (4) The stem cell then migrates through the endothelial cell cytoplasm or paracellularly. The cell will then migrate through matrix to reach the lodging destination. This is facilitated by CXCL12, c-kit ligand, cathepsins, and matrix metalloproteinases. Egress (right hand panel) involves: (1) Matrix transmigration in response to chemokine and growth factor effects. Matrix components involved include collagen IV, laminin, fibronectin, hyaluronic acid, and tenascin; among others. (2) Trans-endothelial migration, and (3) Cell release with disruption of receptor/ligand interactions such as those between between CXCL12 and CXCR4 or CD49d and CD106 (VCAM-1).
Open access
Concise Review: Human Embryonic Stem Cells—What Have We Done? What Are We Doing? Where Are We Going?
- STEM CELLS
- 17-25
- 28 June 2016
Abstract
Ethical issues, the regulatory landscape, and the limited spectrum of diseases were all drawbacks of hESC lines that hiPSC did not have. It is to expect that in foreseeable future hiPSC will take over hESC in both research and clinical applications.
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Video: Dr. Kulkarni from the Kale lab, National Center for Cell Science, Pune, India
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