• Issue

    STEM CELLS Translational Medicine: Volume 7, Issue 5

    373-449
    May 2018

Issue Information

Open Access

Front Cover

  • First Published: 18 April 2018
Description unavailable

Cover Art: Representative images of the In vitro characterization of mesenchymal stem cells (MSCs) show MSC transdifferentiated into chondrocytes (Collagen II; left), osteocytes (Osteopontin; upper right), and adipocytes (FABP4; lower right).

Open Access

Issue Information

  • First Published: 18 April 2018

Previews

Open Access

A Preview of Selected Articles

  • Pages: 373-375
  • First Published: 31 March 2018

Translational Research Articles and Reviews

Cord Blood

Open Access

Ex Vivo Expansion of CD34+CD90+CD49f+ Hematopoietic Stem and Progenitor Cells from Non-Enriched Umbilical Cord Blood with Azole Compounds

  • Pages: 376-393
  • First Published: 02 February 2018
Description unavailable

This study identified a novel structural analog of SB203580 (p38-MAPK inhibitor) that expands hematopoietic stem and progenitor cells (HSPC) from non-enriched, frozen-thawed umbilical cord blood (UCB)–mononucleated cells. The UCB graft expanded with the lead small molecule C7 consists of primitive HSPC phenotype (CD34+CD90+CD49f+), maintains enhanced in vitro colony formation capacity and engrafts both primary and secondary immunodeficient mice. If CD34 selection is further used, this molecule is also able to attain superior HSPC expansion compared to current technologies.

Manufacturing for Regenerative Medicine

Open Access

Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule-1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury

  • Pages: 394-403
  • First Published: 15 February 2018
Description unavailable

MSC were coated with KIM-1 antibody by connecting with palmitic acid protein G, and were injected into the carotid artery of mice with renal artery stenosis. KIM-MSC preferentially homed to the injured kidney, and were retained adjacent to sites of elevated KIM1 expression, in turn resulting in increased therapeutic efficacy, such as improved renal perfusion and capillary density, and attenuated oxidative damage, apoptosis, and fibrosis.

Tissue Engineering and Regenerative Medicine

Open Access

Concise Review: Stem Cell Fate Guided By Bioactive Molecules for Tendon Regeneration

  • Pages: 404-414
  • First Published: 23 March 2018
Description unavailable

Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) and transdifferentiated into tendon stem/progenitor cells (TSPCs) by specific small molecules. iPSCs and embryonic stem cells (ESCs) can differentiated into mesenchymal stem cells (MSCs). FGF-2 could promote cell proliferation. MSCs can differentiate into tendon stem/ progenitor cells in the stimulation of some small molecules, then further develop into mature tenocytes. RAR agonist has been demonstrated to maintain TSPCs phenotype, while TGF-β1 has the similar effect on tenocytes.

Open Access

Concise Review: Altered Versus Unaltered Amniotic Membrane as a Substrate for Limbal Epithelial Cells

  • Pages: 415-427
  • First Published: 23 March 2018
Description unavailable

Damage or disease involving limbal epithelial cells (LECs) may lead to various clinical presentations of limbal stem cell deficiency (LSCD). Amniotic membrane (AM) can be used as a substrate for expansion of LEC for subsequent transplantation in the treatment of LSCD. Different culture techniques on AM are employed and are differing regarding the composition of AM.

Open Access

Quality-Quantity Control Culture Enhances Vasculogenesis and Wound Healing Efficacy of Human Diabetic Peripheral Blood CD34+ Cells

  • Pages: 428-438
  • First Published: 24 March 2018
Description unavailable

Quality-quantity control (QQc) culture of diabetic human PB-CD34+ cells significantly accelerates wound closure, re-epithelialization, and angiogenesis. Higher therapeutic efficacy of post-QQc diabetic human PB-CD34+ cells can be attributed to increased differentiation ability of diabetic CD34+ cells, direct vasculogenesis, and enhanced expression of angiogenic factors and wound-healing genes.

Open Access

Embryonic Stem Cell-Derived Mesenchymal Stem Cells (MSCs) Have a Superior Neuroprotective Capacity Over Fetal MSCs in the Hypoxic-Ischemic Mouse Brain

  • Pages: 439-449
  • First Published: 28 February 2018
Description unavailable

We hypothesize that the increased nuclear factor (NF)-κB activation and, therefore, higher levels of interleukin (IL)-13 production observed in pluripotent stem cell-derived mesenchymal stem cells contributes to the increased anti-inflammatory potential of these cells compared with other types of mesenchymal stem cells.